ABSTRACT
Objective To determine the occurrence of rhabdomyolysis(RM) in the diabetic hyperosmolar hyperglycemic state.Methods Sixteen patients(9 men and 7 women) with diabetic hyperosmolar state were studied.Six of 16(37.50%) patients showed biochemical evidence of RM.The clinical and biochemical features of the patients with RM(group RM) and the patients without RM(group non-RM) were compared.Results Patients with RM showed a 30-fold increase in serum creatine phospholipase(CK) and 50-fold in myoglobin (Mb) when compared to the patients without RM.Significantly higher mean glucose level,serum sodium level and serum osmolality were found in patients with RM than in those without RM(P
ABSTRACT
Objective To evaluate the clinical diagnostic criteria of latent autoimmune diabetes of adults(LADA).Methods A total of 268 subjects consisted of 168 patients with type 2 diabetes(T2DM) and of 100 normal controls were involved in the study.The body mass index(BMI) was calculated by formula(kg/m~2) and the levels of fasting blood glucose(FBG),postprandial blood glucose(PBG),fasting C-peptide(FC-P),postprandial Cpeptide(PC-P),GAD antibody(GADA),ICA,IAA and IA-2 antibody were detected. The patients with positive antibody in T2DM group were considered as LADA and the others in T2DM group still as T2DM.Results The GADA,ICA,IA-2 antibody and IAA antibody were detected in 21.18%,14.29%,1.19% and 0.60% of patients with T2DM,respectively.The indexes such as the age of onset ≤ 40 years old,overt symptom,ketosis,without chronic complication and hypertension,BMI90.00%).Conclusion The GADA is the most specific antibody in the diagnosis of patients with autoimmune diabetes.The indexes such as the age of onset≤40 years,overt symptom,ketosis,without chronic complication and hypertension,BMI